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Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Division on Engineering and

By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

Super dangerous elements (EHSs)² may be published by chance because of chemical spills, commercial explosions, fires, or injuries regarding railroad autos and vehicles transporting EHSs. staff and citizens in groups surrounding commercial amenities the place EHSs are synthetic, used, or saved and in groups alongside the nation's railways and highways are in all likelihood prone to being uncovered to airborne EHSs in the course of unintentional releases or intentional releases by means of terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental security business enterprise (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality facts in rodents. As a part of its efforts to boost acute publicity guide degrees for EHSs, EPA and the company for poisonous components and ailment Registry (ATSDR) in 1991 asked that the nationwide examine Council (NRC) increase guidance for developing such degrees. based on that request, the NRC released guidance for constructing neighborhood Emergency publicity degrees for detrimental elements in 1993. accordingly, typical working techniques for constructing Acute publicity instruction degrees for detrimental ingredients used to be released in 2001, delivering up-to-date strategies, methodologies, and different directions utilized by the nationwide Advisory Committee (NAC) on Acute publicity instruction degrees for dangerous ingredients and the Committee on Acute publicity instruction degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently assessment the AEGLs constructed by means of NAC. according to that request, the NRC prepared inside its Committee on Toxicology (COT) the Committee on Acute publicity guide degrees, which ready this file. Acute publicity instruction degrees for chosen Airborne chemical compounds is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.

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Upon discharge from the hospital 15 days postexposure, the patient was free of any symptoms. A 21-year-old man was hospitalized following accidental exposure to DMF at work (exposure quantity and route not characterized) (Chary 1974). On hospital admission, he experienced upper abdominal pain radiating in his back. Nausea and vomiting, epigastric tenderness, and an erythematous rash on his hands and forearms (possibly suggesting direct skin contact with DMF) developed. /liter (L), but a cholecystogram and intravenous cholangiogram were normal.

1991). 1 m3 chamber with airflow of 500 L/min), and a second monkey was exposed head-only (acrylic helmet with airflow rate of 10 L/min). Mean analytic concentrations for the 10-day period were 509 and 385 ppm, respectively. Clinical signs were recorded daily during exposure, and body weight was recorded 1 day before exposure, on study day 8, and after the last exposure. Blood was collected for hematology and clinical chemistry analysis 1 day before exposure at the end of the first exposure day and following the last exposure day.

Groups of 10 male Sprague-Dawley rats inhaled DMF at measured concentrations of 0, 81, 153, 313, 441, or 991 ppm for 4 h in a 200-L dynamic inhalation chamber (with adjustable laminar airflow ranging from 10 to 20 m3/h) at 23°C (Roure et al. 1996). The concentration of DMF in the chamber was monitored continuously by gas-liquid chromatography, and periodic air samples were also collected with charcoal-packed glass tubes, desorbed with disulfide, and analyzed by gas-liquid chromatography. Serum SDH and glutamate dehydrogenase (GDH) were measured 24, 48, and 72 h postexposure (Table 1-5).

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